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REFEREED PUBLICATIONS


24.  D. C. Jeong, P. S. Tsai and D. Kleinfeld, All-optical osteotomy to create windows for transcranial imaging in mice. Optics Express 21:23160-23168 (2013).

23.  P. Blinder*, P. S. Tsai*, J. P. Kaufhold, P. M. Knutsen, H. Suhl and D. Kleinfeld, The cortical angiome: An interconnected vascular network with noncolumnar
          patterns of blood flow. Nature Neuroscience 16:889-897 (2013).


22.  A. Y. Shih, P. Blinder, P. S. Tsai, B. Friedman, G. Stanley, P. D. Lyden and D. Kleinfeld,The smallest stroke: Occlusion of one penetrating vessel leads to
          infarction and a cognitive deficit. Nature Neuroscience  16:55-63 (2013).


21.  J. P. Kaufhold, P. S. Tsai, P. Blinder and D. Kleinfeld, Vectorization of optically sectioned brain microvasculature: Learning aids completion of vascular graphs
          by
connecting gaps and deleting open-ended segments, Medical Image Analysis (2012).

20.  A. Y. Shih, P. J. Drew, C. Mateo,
P. S. Tsai and D. Kleinfeld, A polished and reinforced thinned skull window for long-term imaging and optical manipulation of
          the mouse cortex,. Journal of Visualized Neuroscience, http://www.jove.com/video/3742, (2011).

19.  D.C. Jeong,
P. S. Tsai and D. Kleinfeld, Prospect for feedback guided surgery with ultra-short pulsed laser light, Current Opinions in Neurobiology, 22:24-33,
         
(2011).

18.  D. Kleinfeld, A. Bharioke, P. Blinder, D. D. Bock, K. L. Briggman, D. B. Chklovskii, W. Denk, M. Helmstaedter, J. P. Kaufhold, W-C. A. Lee, H. S. Meyer, K. D.
         
Micheva, M. Oberlaender, S. Prohaska, R. C. Reid, S. J. Smith, S. Takemura,
P. S. Tsai and B. Sakmann, Large-scale automated histology in the pursuit of
         
connectomes.
Journal of Neuroscience 31:16125-16138, (2011).

17.  D. Kleinfeld, P. Blinder, P. J. Drew, J. D. Driscoll, A. Muller, P. S. Tsai and A. Y. Shih, A guide to delineate the logic of neurovascular signaling in the brain.
         
Frontiers in Neuroenergetics, 3:1-9 (2010).

16.  P. J. Drew, A. Y. Shih, P. Knutsen, D. Davalos, P. Blinder, K. Akassoglou,  P. S. Tsai and D. Kleinfeld, Chronic imaging and optical manipulation of cortical cells
         
and microvessels through a large-area polished and reinforced thinned-skull.
Nature Methods.,981-984, (2010).

15.  D. N. Vitek, D. E. Adams, A. Johnson,
P. S. Tsai, S. Backus, C. G. Durfee, D. Kleinfeld and J. A. Squier, Temporally focused femtosecond laser pulses for low
         
numerical aperture micromachining through optically transparent materials
. Optics Express 18:18086-18094, (2010).

14.  B. Chen, B. Friedman, Q. Cheng,
P. S. Tsai, E. Schim, D. Kleinfeld, and P. D. Lyden, Severe blood-brain barrier disruption and surronding tissue injury, Stroke,
         
40
, E666-E674 (2009).

13.  P. S. Tsai
, J. Kaufhold, P. Blinder, B. Friedman, P.J. Drew, H.J. Karten, P. D. Lyden and D. Kleinfeld, Correlations of neuronal and microvascular densisties in
         
murine cortex revealed by direct counting and colocalization of nuclei and vessels,
Journal of Neuroscience, 29(46) 14553-14570 (2009).

12.  P. S. Tsai
, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier and D. Kleinfeld, Plasma-mediated ablation: An optical tool for submicrometer surgery on
         
neuronal and vascular systems.
Current Opinion in Biotechnology, 20(1), 90-99 (2009).

11.  B. Friedman, C. Schachtrup,
P. S. Tsai, A. Y. Shih, J. Nordberg, K. Akassoglou, D. Kleinfeld and P. D. Lyden, Acute vascular disruption and Aquaporin 4 loss
         
after stroke,
Stroke, 40(6), 2182-2190, (2009).

10.  A. Shih, B. Friedman, P. Drew,
P. S. Tsai, P. Lyden, and D.Kleinfeld, Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex
         
after focal stroke,
Journal of Cerebral Blood Flow and Metabolism, 29, 738-751. (2009).

9.    P. S. Tsai
, B. Migliori, K. Campbell, T. N. Kim, Z. Kam, A. Groisman, and D. Kleinfeld, Spherical aberration correction in nonlinear microscopy and optical
         
ablation using a transparent deformable membrane,
Applied Physics Letters, 91(19), 191102 (2007).

8.    Q. T. Nguyen,
P. S. Tsai, D. Kleinfeld, MPScope: A versatile software suite for multiphoton microscopy, Journal of Neuroscience Methods, 156 (1-2), 351-359
         
(2006).


7.    G. O. Clay, A. C. Millard, C. B. Schaffer, J. Aus-der-Au,
P. S. Tsai, J. A. Squier, and D. Kleinfeld, Spectroscopy of third harmonic generation: Evidence for
          resonances in model compounds and ligated hemoglobin
, Journal of the Optical Society of America B, 23 932 (2006).

6.    N. Nishimura, C. B. Schaffer, B. Friedman,
P. S. Tsai, P. D. Lyden, and D. Kleinfeld, Targeted insult to individual subsurface cortical blood vessels using
          ultrashort laser pulses: Three models of stroke
. Nature Methods, 3, 99 (2006).

5.    C. B. Schaffer, B. Friedman, N. Nishimura, L. F. Schroeder,
P. S. Tsai, F. F. Ebner, P. D. Lyden, and D. Kleinfeld, Two-photon imaging of cortical surface
          microvessels reveals a robust redistribution in blood flow after vascular occlusion,
Public Library of Science Biology, 4 (2), e22 (2006).

4.    P. S. Tsai
, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, All-Optical
          Histology Using Ultrashort Laser Pulses
, Neuron, 39, 27 (2003).

3.    J. A. Davis,
P. S. Tsai, D.M. Cottrell, T. Sonehara, J. Amako, Transmission Variations in Liquid Crystal Spatial Light Modulators Caused by Interference and   
          Diffraction Effects.
Optical Engineering, 38, 1051 (1999).

2.    J. A. Davis,
P. S. Tsai, K.G. D’Neilly, Simple Technique for Determining the Extraordinary Axis Direction for Twisted-Nematic Liquid Crystal Spatial Light
          Modulators
, Optical Engineering, 38, 929 (1999).

1.    J. A. Davis, I. Moreno,
P. S. Tsai, Polarization Eigenstates for Twisted-Nematic Liquid-Crystal Displays, Applied Optics, 37, 937 (1998).