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SELECTED PUBLICATIONS

C. I. Mateo, P. M. Knutsen, P. S. Tsai, A. Y. Shih and D. Kleinfeld, Entrainment of arteriole vasomotor fluctuations by neuronal activity: A basis of blood oxygen level dependent "resting state" connectivity across cortex. Neuron (2017) 20(3):406-416

P. S. Tsai, C. Mateo, J.J. Field, C.B. Schaffer, M.E. Anderson & D. Kleinfeld, Ultra-large field-of-view two-photon microscopy. Optics Express (2015) 23: 13833-13847

D. C. Jeong, P. S. Tsai and D. Kleinfeld, All-optical osteotomy to create windows for transcranial imaging in mice. Optics
Express 21:23160-23168 (2013).

P. Blinder*, P. S. Tsai*, J. P. Kaufhold, P. M. Knutsen, H. Suhl and D. Kleinfeld, The cortical angiome: An interconnected
vascular network with noncolumnar patterns of blood flow. Nature Neuroscience 16:889-897 (2013).

A. Y. Shih, P. Blinder, P. S. Tsai, B. Friedman, G. Stanley, P. D. Lyden and D. Kleinfeld,The smallest stroke: Occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nature Neuroscience  16:55-63 (2013).

J. P. Kaufhold, P. S. Tsai, P. Blinder and D. Kleinfeld, Vectorization of optically sectioned brain microvasculature: Learning aids completion of vascular graphs by connecting gaps and deleting open-ended segments, Medical Image Analysis (2012).

P. J. Drew, A. Y. Shih
, P. Knutsen, D. Davalos, P. Blinder, K. Akassoglou, P. S. Tsai and D. Kleinfeld, Chronic imaging and optical manipulation of cortical cells and microvessels through a large-area polished and reinforced thinned-skull. Nature Methods.,981-984, (2010).

D. N. Vitek, D. E. Adams, A. Johnson,
P. S. Tsai, S. Backus, C. G. Durfee, D. Kleinfeld and J. A. Squier, Temporally focused femtosecond laser pulses for low numerical aperture micromachining through optically transparent materials. Optics Express 18:18086-18094, (2010).

P. S. Tsai
, J. Kaufhold, P. Blinder, B. Friedman, P.J. Drew, H.J. Karten, P. D. Lyden and D. Kleinfeld, Correlations of neuronal and microvascular densisties in murine cortex revealed by direct counting and colocalization of nuclei and vessels, Journal of Neuroscience, 29(46) 14553-14570 (2009).

P. S. Tsai, B. Migliori, K. Campbell, T. N. Kim, Z. Kam, A. Groisman, and D. Kleinfeld, Spherical aberration correction in nonlinear microscopy and optical ablation using a transparent deformable membrane, Applied Physics Letters, 91(19), 191102 (2007).

N. Nishimura, C. B. Schaffer, B. Friedman,
P. S. Tsai, P. D. Lyden, and D. Kleinfeld, Targeted insult to individual subsurface cortical blood vessels using ultrashort laser pulses: Three models of stroke. Nature Methods, 3, 99 (2006).

C. B. Schaffer, B. Friedman, N. Nishimura, L. F. Schroeder,
P. S. Tsai, F. F. Ebner, P. D. Lyden, and D. Kleinfeld, Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion, Public Library of Science Biology, 4 (2), e22 (2006)

P. S. Tsai
, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, All-Optical Histology Using Ultrashort Laser Pulses, Neuron, 39, 27 (2003).

P. S. Tsai, N. Nishimura, E. J. Yoder, E. M. Dolnick, G. A. White, and D. Kleinfeld, Principles, design, and construction of a two photon laser scanning microscope for in vitro and in vivo brain imaging in In Vivo Optical Imaging of Brain Function, R. D. Frostig, ed.,Broca Raton, CRC Press, pp. p113-171 (2002).

J. A. Davis,
P. S. Tsai, D.M. Cottrell, T. Sonehara, J. Amako, Transmission Variations in Liquid Crystal Spatial Light Modulators Caused by Interference and Diffraction Effects. Optical Engineering, 38, 1051 (1999).

J. A. Davis, I. Moreno,
P. S. Tsai, Polarization Eigenstates for Twisted-Nematic Liquid-Crystal Displays, Applied Optics, 37, 937 (1998).